Hereditary Spastic Paraparesis
Hereditary Spastic Paraparesis (HSP) is a group of inherited disorders that cause progressive stiffness and weakness in the lower limbs due to dysfunction of the spinal cord.
Symptoms
- Progressive leg stiffness and spasticity
- Weakness in lower limbs
- Difficulty walking or maintaining balance
- Urinary urgency or incontinence
- Fatigue from increased effort in movement
Causes & Risk Factors
- Genetic mutations (autosomal dominant or recessive)
- Family history of similar gait disorders
- Dysfunction of corticospinal tract in spinal cord
Diagnosis
- Clinical neurological evaluation
- Genetic testing
- MRI to rule out other spinal cord lesions
- Nerve conduction studies
Effective Treatment Options
- Physiotherapy to manage spasticity and improve gait
- Antispasmodic medications (e.g., baclofen)
- Assistive walking devices or orthotics
- Occupational therapy for daily activity support
Frequently Asked Questions
Can HSP be cured?
There is no cure, but physiotherapy can significantly improve function and reduce symptoms.
Is HSP always progressive?
Yes, but the rate of progression varies by type and individual.
