Condition guide
Hereditary Spastic Paraparesis - Overview
Hereditary spastic paraparesis (HSP) refers to a group of inherited conditions that cause stiffness and weakness in the legs. The course can vary by genetic type.
Symptoms
- Progressive leg stiffness and spasticity
- Weakness in lower limbs
- Difficulty walking or maintaining balance
- Urinary urgency or incontinence
- Fatigue from increased effort in movement
Causes & Risk Factors
- Genetic mutations (autosomal dominant or recessive)
- Family history of similar gait disorders
- Dysfunction of corticospinal tract in spinal cord
Diagnosis
- Clinical neurological evaluation
- Genetic testing
- MRI to rule out other spinal cord lesions
- Nerve conduction studies
Effective Treatment Options
- Physiotherapy to manage spasticity and improve gait
- Antispasmodic medications (e.g., baclofen)
- Assistive walking devices or orthotics
- Occupational therapy for daily activity support
Frequently Asked Questions
Can HSP be cured?
There is currently no cure for HSP. Physiotherapy can help maintain function and manage symptoms.
Is HSP always progressive?
The course varies by the underlying genetic condition. Some forms starting in early childhood can be non-progressive; others progress at a variable rate.
Sources and further reading
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